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MilliporeSigma™ Complement C8, Human, Protein

Catalog No. 204896250UG Shop All MilliporeSigma Products
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20-489-6250UG 250 μg
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Catalog No. 20-489-6250UG Supplier MilliporeSigma™ Supplier No. 204896250UG
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Description

Native, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64kDa (α), 64kDa (β), and 22kDa (γ). Present in normal human serum at 55μg/mL. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation In PBS, pH 7.2.
Purification Method SDS-PAGE
Quantity 250 μg
Immunogen Complement C8
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Native
Form Liquid
Purity or Quality Grade ≥85%
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