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MilliporeSigma™ Granzyme A, Human, Recombinant Protein, E. coli

Catalog No. 36804410UG Shop All MilliporeSigma Products
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36-804-410UG 10μg
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Catalog No. 36-804-410UG Supplier MilliporeSigma™ Supplier No. 36804410UG
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Description

Recombinant, human granzyme A expressed in E. coli. Granzyme A is a trypsin-like serine protease secreted by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. A proapoptotic enzyme that induces cell death through caspase-independent mechanism, causing single-stranded DNA nicking and other apoptotic features including nuclear fragmentation, chromatin condensation, loss of mitochondrial potential, and membrane blebbing. Granzyme A is also known to bind to and cleave nucleolin and activate the thrombin receptor on neuronal cells and astrocytes. It also cleaves and activates interleukin-1β. Note: The M.W. is that of a homodimer.
TRUSTED_SUSTAINABILITY

Specifications

Formulation In 520mM NaCl, 50mM MES, 10% glycerol, pH 6.0.
Quantity 10μg
Source E. coli
Immunogen Granzyme A
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Recombinant
Form Liquid
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