MilliporeSigma™ MMP/TIMP Family Sampler kit

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ ASK101EA

Catalog No. ASK101EA

Description

Specifically detects MMP/TIMP Family Clone: in samples, and it is validated for

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. All MMPs share: sequence homology, a catalytic mechanism dependent upon a zinc ion at the active center, ability to cleave one or more extracellular matrix components, secretion as zymogens which are activated by removal of an approximately 10kDa segment from the N-terminus, and regulation by endogenous inhibitors. These enzymes are involved in normal physiological processes as well as in metastasis. MMP-2 and MMP-9 are members of the gelatinase family and elevated levels may be correlated with metastatic potential. MMP-1 is also known as interstitial collagenase and MMP-3 as stromelysin-1. Activation and activity of the MMP's are regulated by the TIMP (tissue inhibitors of metalloproteinase) family members. TIMP-1 preferentially regulates MMP-9 and TIMP-2 regulates MMP-2.

Specifications

• Antigen: MMP/TIMP Family
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Test Specificity: Contains 20μg of each antibody. Includes Anti-MMP-1, Anti-MMP-2, Anti-MMP-3, Anti-MMP-9, Anti-TIMP-1, and Anti-TIMP-2.
• Content And Storage: −20°C

• Classification: Monoclonal
• Formulation: 20μg of each antibody in 100mM sodium phosphate buffer, 0.1% BSA, pH 7.4.
• Quantity: 1 Kit
• Primary or Secondary: Primary
• Includes: 20μg of each antibody in 100mM sodium phosphate buffer, 0.1% BSA, pH 7.4.
• Form: Purified

For Research Use Only