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MilliporeSigma™ Orexin A (14-33) (Ab-1), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Catalog No. PC3451SET Shop All MilliporeSigma Products
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Unconjugated
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PC3451SET 1 Set Unconjugated
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Catalog No. PC3451SET Supplier MilliporeSigma™ Supplier No. PC3451SET

Description

Rabbit Polyclonal Antibody

Specifically detects Orexin A (14-33) (Ab-1) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for ELISA, Immunofluorescence, Immunohistochemistry (Frozen)

The hypothalamus has been shown to play a central role in the regulation of energy homeostasis and in the control of feeding behavior. Two homologous peptides have recently been identified for which the message and protein have been localized to the lateral hypothalamus. Orexin A (hypocretin 1), a 33 amino acid peptide, and orexin B (hypocretin 2), a 28 amino acid peptide, are both encoded by a single mRNA transcript. These peptides stimulate food consumption in a dose-dependent manner when administered intracerebroventricularly, and precursor mRNA levels are upregulated upon fasting. In addition to the orexins (hypocretins), two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides. Competitive radioligand binding assays suggest that the orexin receptor-1 is selective for orexin A, while orexin receptor-2 is nonselective for both peptides.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Orexin A (14-33) (Ab-1)
Applications ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Classification Polyclonal
Conjugate Unconjugated
Formulation 100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Host Species Rabbit
Immunogen a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
Quantity 1 Set
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Includes 100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Target Species Bovine, Human, Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG
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