MilliporeSigma™ p53 Sampler kit

Catalog No.	Quantity	Conjugate
ASK071EA	1 Kit	Unconjugated

Catalog No. ASK071EA Supplier MilliporeSigma™ Supplier No. ASK071EA

Description

Mouse Monoclonal Antibody

Specifically detects p53 Clone: in samples, and it is validated for

The human p53 tumor suppressor gene encodes a 393 amino acid phosphoprotein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage. This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes. The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.

Specifications

• Antigen: p53
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 20μg of each antibody in 200μL (100μg/ml) of 0.05 M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
• Host Species: Mouse
• Quantity: 1 Kit
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: 20μg of various p53 antibodies.
• Includes: 20μg of each antibody in 200μL (100μg/mL) of 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
• Content And Storage: 2°C to 8°C
• Form: Liquid

For Research Use Only