MilliporeSigma™ Pam3Cys-Ser-(Lys)4, Hydrochloride, Protein
Manufacturer: MilliporeSigma™ 5063502MG
DescriptionA cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
|Following reconstitution, aliquot and freeze (−20°C). Avoid freeze/thaw cycles of solutions.|
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