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MilliporeSigma™ γ-Secretase Inhibitor XXIII, Aβ42-Selective, Calbiochem, Protein

Catalog No. 5657925MG Shop All MilliporeSigma Products
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56-579-25MG 5 mg
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Catalog No. 56-579-25MG Supplier MilliporeSigma™ Supplier No. 5657925MG
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Description

A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100mg/kg, p.o.) in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Preparation Method DMSO (25mg/mL)
Purification Method HPLC
Quantity 5 mg
Immunogen γ-Secretase Inhibitor XXIII, Aβ42-Selective
Storage Requirements Following reconstitution, aliquot and freeze (−20°C). Stock solutions are stable for up to 2 months at −20°C.
Regulatory Status RUO
Recombinant Native
Form Solid
Purity or Quality Grade ≥95%
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