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MilliporeSigma™ Serotonin 3 (5-HT3) Receptor (444-457), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Catalog No. PC3471SET Shop All MilliporeSigma Products
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Unconjugated
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PC3471SET 1 Set Unconjugated
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Catalog No. PC3471SET Supplier MilliporeSigma™ Supplier No. PC3471SET

Description

Rabbit Polyclonal Antibody

Specifically detects Serotonin 3 (5-HT3) Receptor (444-457) Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen)

The monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways. The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C. In contrast, the 5-HT3 receptor is a ligand-gated ion channel that mediates a fast excitatory response. This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABAA and NMDA receptors. Although the 5-HT3 receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT3 receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input. Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT3 immunoreactivity, primarily including interneurons and motor neurons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Serotonin 3 (5-HT3) Receptor (444-457)
Applications Immunohistochemistry (Frozen)
Classification Polyclonal
Conjugate Unconjugated
Formulation 25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Host Species Rabbit
Immunogen a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Quantity 1 Set
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Includes 25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Target Species Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG
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