MilliporeSigma™ Serotonin 3 (5-HT₃) Receptor (444-457), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC3471SET

Catalog No. PC3471SET

Description

Specifically detects Serotonin 3 (5-HT₃) Receptor (444-457) Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen)

The monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways. The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C. In contrast, the 5-HT₃ receptor is a ligand-gated ion channel that mediates a fast excitatory response. This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABA_A and NMDA receptors. Although the 5-HT₃ receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT₃ receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input. Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT₃ immunoreactivity, primarily including interneurons and motor neurons.

Specifications

• Antigen: Serotonin 3 (5-HT₃) Receptor (444-457)
• Conjugate: Unconjugated
• Format: purified
• Immunogen: a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT₃) receptor, conjugated to KLH
• Quantity: 1 Set
• Storage Requirements: 2°C to 8°C
• Monoclonal or Polyclonal: Polyclonal
• Includes: 25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.

• Applications: Immunohistochemistry (Frozen)
• Formulation: 25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
• Host Species: Rabbit
• Isotype: IgG
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the serotonin 3 (5-HT₃) receptor in mouse and rat brain tissue. Supplied with a control peptide.
• Target Species: Murine, Rat

For Research Use Only