Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ Serotonin 3 (5-HT3) Receptor (444-457), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC3471SET

Catalog No. PC3471SET

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Serotonin 3 (5-HT3) Receptor (444-457) Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen)

The monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways. The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C. In contrast, the 5-HT3 receptor is a ligand-gated ion channel that mediates a fast excitatory response. This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABAA and NMDA receptors. Although the 5-HT3 receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT3 receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input. Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT3 immunoreactivity, primarily including interneurons and motor neurons.
Specifications

Specifications

Serotonin 3 (5-HT3) Receptor (444-457)
Unconjugated
purified
a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
1 Set
2°C to 8°C
Polyclonal
25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunohistochemistry (Frozen)
25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Rabbit
IgG
RUO
Primary
Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Murine, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only