MilliporeSigma™ Vanilloid Receptor Like Protein-1 (744-761), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set

Catalog No.	Quantity	Conjugate
PC4211SET	1 Set	Unconjugated

Catalog No. PC4211SET Supplier MilliporeSigma™ Supplier No. PC4211SET

Description

Rabbit Polyclonal Antibody

Specifically detects Vanilloid Receptor Like Protein-1 (744-761) Clone: in Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Frozen), Immuno Blotting

The detection of noxious stimuli (chemical, mechanical, or thermal), a process referred to as nociception, occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke a perception of pain which initiates appropriate protective reflexes. Vanilloid-containing compounds which include capsaicin, the active ingredient in hot chilli peppers, selectively depolarize nociceptors to activate the nociceptive pathway. The receptor for capsaicin, vanilloid receptor 1 (VR1), has been identified as a nonselective cation channel that resembles members of the transient receptor potential (TRP) family of ion channels. The vanilloid receptor 1 protein functions both as a receptor for capsaicin and a transducter of noxious thermal stimuli. Immunocytochemical and mRNA localization studies suggest that VR1 protein is localized to small-diameter sensory neurons within the dorsal root ganglia and nerve terminals in the dorsal horn. A capsaicin-receptor homolog has recently been identified, designated the vanilloid-receptor-like protein 1 (VRL-1). VRL-1 is activated by high temperatures and is expressed in medium- to large-diameter neurons within sensory ganglia.

Specifications

• Antigen: Vanilloid Receptor Like Protein-1 (744-761)
• Applications: Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: 100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
• Host Species: Rabbit
• Immunogen: a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
• Quantity: 1 Set
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
• Includes: 100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
• Target Species: Mouse, Rat
• Content And Storage: 2°C to 8°C
• Form: Purified
• Isotype: IgG

For Research Use Only