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Cayman Chemical EmetInhydrochLRIde hydrat 50mg
Supplier: Cayman Chemical 2104850 MG
An alkaloid with diverse biological activities; active against several strains of E. histolytica amoebae (IC50s = 0.73-10.22 μg/ml); inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay); increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM); cytotoxic to HeLa cells; reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 0.46 and 0.5 μM, respectively); induces emesis in ferrets at 5 mg/kg, an effect that can be prevented by ondansetron
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