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Medchemexpress LLC Emixustat hydrochloride | 1141934-97-5 | 99.3% | 299.84 | 50 MG
Supplier: Medchemexpress LLC HY19720A50MG
Emixustat hydrochloride (ACU-4429) is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. It functions as a visual cycle modulator by inhibiting retinol isomerization. This compound shows potential for research into vision disorders such as age-related macular degeneration (AMD).
- Reduces the production of 11-cis-retinol in a concentration-dependent manner, thereby inhibiting RPE65 activity.
- Reduces the conductance of retinal cation channels after dark adaptation in rats.
- Dose-dependently reduces retinal neovascularization in an Oxygen-Induced Retinopathy (OIR) mouse model.
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