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Medchemexpress LLC Emixustat hydrochloride (ACU-4429 hydrochloride) | 1141934-97-5 | 99.3% | 299.84 | 1 ML
Supplier: Medchemexpress LLC HY19720A10MM/1ML
Emixustat hydrochloride (ACU-4429 hydrochloride) is an orally active RPE65 inhibitor. It functions as a visual cycle modulator, regulating visual cycle activity by inhibiting retinol isomerization, and shows potential for studying vision disorders, including age-related macular degeneration (AMD).
- Orally active RPE65 inhibitor
- Functions as a visual cycle modulator
- Regulates visual cycle activity by inhibiting retinol isomerization
- Potential for studying vision disorders such as age-related macular degeneration (AMD)
- Inhibits RPE65 activity with an IC50 of 4.4 nM
- Reduces 11-cis-retinol production
- Shown to inhibit neovascularization and protect the retina in an oxygen-induced retinopathy mouse model
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