Enalaprilat, Thermo Scientific Chemicals

Description

The active metabolite of enalapril

Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

Solubility
Soluble in water with heating (∼60°C)

Notes
Store in a cool dry place. Keep away from oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 76420-72-9
• Molecular Formula: C18H24N2O5
• Molecular Weight (g/mol): 348.399
• MDL Number: MFCD00865786
• InChI Key: LZFZMUMEGBBDTC-QEJZJMRPSA-N
• Synonym: enalaprilat, enalapril acid, enalaprilate, enalaprilatum, enalapril diacid, enalaprilic acid, enalaprilat anhydrous, n-1s-1-carboxy-3-phenylpropyl-l-alanyl-l-proline, unii-q508q118jm
• PubChem CID: 5462501
• ChEBI: CHEBI:4786
• IUPAC Name: (2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
• SMILES: CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O

• Melting Point: 148°C to 151°C
• Color: White
• Quantity: 50 mg
• Merck Index: 14,3568
• Solubility Information: Soluble in water with heating (∽60°C)
• Formula Weight: 384.42
• Physical Form: Crystalline Solid
• Chemical Name or Material: Enalaprilat

Safety and Handling

EINECSNumber	278-459-3
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only