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Medchemexpress LLC Enasidenib (mesylate) | 1650550-25-6 | MFCD29472245 | 99.7% | 569.48 | 50 MG
SDP

Catalog No. 5000387756
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Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.

  • First-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.
  • Reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells.
  • Induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells.
  • Significantly improves survival in an IDH2-mutant acute myeloid leukemia (AML) primary xenograft mouse model.
  • Leads to a reduction in 2-HG in vivo.
  • Restores megakaryocyte-erythroid progenitor (MEP) differentiation.

Catalog No. 50-003-87756 Supplier Medchemexpress LLC Supplier No. HY18690A50MG
May include imposed supplier surcharges.
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Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.

  • First-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.
  • Reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells.
  • Induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells.
  • Significantly improves survival in an IDH2-mutant acute myeloid leukemia (AML) primary xenograft mouse model.
  • Leads to a reduction in 2-HG in vivo.
  • Restores megakaryocyte-erythroid progenitor (MEP) differentiation.

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