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Medchemexpress LLC Endo-BCN-PEG4-val-cit-pab-mmae | 2762519-08-2 | 98.8% | 1546.93 | C80H127N11O19 | 5 MG
SDP

Catalog No. 5000203037
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endo-BCN-PEG4-val-cit-pab-mmae is a cleavable antibody-drug conjugate (ADC) linker conjugated to monomethyl auristatin E (MMAE). It contains a bicyclo[6.1.0]non-4-yn (BCN) click handle and a four-unit polyethylene glycol (PEG4) spacer, and uses a Val-Cit-PAB dipeptide self-immolative linker for enzymatic (cathepsin) release of the payload. The material is supplied as a white to off-white solid and is unstable in solution; freshly prepare solutions.

  • Cleavable Val-Cit-PAB dipeptide linker for enzymatic release.
  • BCN handle enables strain-promoted alkyne-azide cycloaddition (SPAAC).
  • PEG4 spacer increases hydrophilicity and solubility.
  • Suitable for synthesizing antibody-drug conjugates and linker-drug studies.
  • Supplied as a white to off-white solid; unstable in solution - prepare fresh.

Catalog No. 50-002-03037 Supplier Medchemexpress LLC Supplier No. HY1411555MG
May include imposed supplier surcharges.
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endo-BCN-PEG4-val-cit-pab-mmae is a cleavable antibody-drug conjugate (ADC) linker conjugated to monomethyl auristatin E (MMAE). It contains a bicyclo[6.1.0]non-4-yn (BCN) click handle and a four-unit polyethylene glycol (PEG4) spacer, and uses a Val-Cit-PAB dipeptide self-immolative linker for enzymatic (cathepsin) release of the payload. The material is supplied as a white to off-white solid and is unstable in solution; freshly prepare solutions.

  • Cleavable Val-Cit-PAB dipeptide linker for enzymatic release.
  • BCN handle enables strain-promoted alkyne-azide cycloaddition (SPAAC).
  • PEG4 spacer increases hydrophilicity and solubility.
  • Suitable for synthesizing antibody-drug conjugates and linker-drug studies.
  • Supplied as a white to off-white solid; unstable in solution - prepare fresh.

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