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Medchemexpress LLC Endothelin-1 (1-31) (Human) | 133972-52-8 | 99.7% | 3628.16 | 1 MG
Supplier: Medchemexpress LLC HYP4159A1MG
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent derived from the selective hydrolysis of big ET-1 by chymase. In vitro, it induces human mesangial cell proliferation and ERK activation. In vivo, it induces contraction in the mouse mesenteric artery, possibly mediated by the ETA receptor. This contraction can be increased by aging, and gender differences have been observed in chronic diabetic conditions.
- Potent vasoconstrictor.
- Hypertensive agent.
- Derived from selective hydrolysis of big ET-1 by chymase.
- Induces human mesangial cell proliferation and ERK activation in vitro.
- Induces contraction in mouse mesenteric artery in vivo.
- Possible ETA receptor mediation.
- Effects can be increased by aging.
- Gender differences observed in chronic diabetic conditions.
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