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Cayman Chemical EnfuvIrtIde 10mg
Supplier: Cayman Chemical 2409710 MG
A biomimetic peptide inhibitor of HIV-1 fusion with CD4+ cells; inhibits HIV-1 infectivity of HeLa cells stably expressing CD4 by the HXB2 strain (IC50 = 692 pM) and by clinical isolates (IC90s = 6.1-61 nM) in a single-cycle infectivity assay; inhibits genomic integration of HIV-1 into human intraepithelial vaginal cells and PBMCs (IC50s = 51.2 and 13.58 μM, respectively); binds to a recombinant molecular mimic of HIV-1 glycoprotein gp41 (Kd = 32 nM); binds to recombinant FPRs expressed in rat basophilic leukemia cells (IC50 = 5 nM) and attracts and activates human peripheral blood phagocytes, but not T lymphocytes, in vitro (100 nM)
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