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Medchemexpress LLC ENMD-1198 | 864668-87-1 | 98.48% | 311.42 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1619610MM/1ML

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ENMD-1198 (IRC-110160) is an orally active microtubule destabilizing agent and a 2-methoxyestradiol analogue. It exhibits antiproliferative and antiangiogenic activity by inhibiting HIF-1alpha and STAT3 in human HCC cells, leading to reduced tumor growth and vascularization.

  • Acts as a microtubule destabilizing agent.
  • Shows antiproliferative and antiangiogenic activity.
  • Inhibits HIF-1alpha and STAT3.
  • Causes dose-dependent inhibition of HCC cell growth.
  • Abrogates EGF-induced phosphorylation of key signaling proteins.
  • Inhibits growth of hepatocellular carcinoma in xenograft models.

Catalog No. 50-003-91875


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