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Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 10 MG
Supplier: Medchemexpress LLC HY10987A50MG
ENMD-2076 is a multi-targeted kinase inhibitor, demonstrating significant activity against Aurora A, Flt3, KDR/VEGFR2, and other kinases. It effectively inhibits cellular autophosphorylation and induces G2-M-phase arrest and apoptosis in various cell lines. In vivo studies show dose-dependent inhibition of tumor growth and tumor regression, with the compound being well tolerated.
- Inhibits multiple kinases including Aurora A, Flt3, VEGFR2
- Induces G2-M-phase arrest and apoptosis
- Demonstrates antiproliferative activity against human cell lines
- Inhibits cellular Flt3 ligand (FL)-induced Flt3 autophosphorylation
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation
- Inhibits VEGFR2/KDR autophosphorylation
- Leads to dose-dependent inhibition of tumor growth in vivo
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