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Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 100 MG
Supplier: Medchemexpress LLC HY10987A1MG
ENMD-2076 is a multi-targeted kinase inhibitor with high selectivity towards Aurora A versus Aurora B. It inhibits HUVEC growth and shows antiproliferative effects on human leukemia cell lines. This compound induces G2-M-phase arrest and apoptosis in U937 cells and inhibits Flt3 and Kit autophosphorylation. In vivo, ENMD-2076 demonstrates dose-dependent inhibition of tumor growth and is well tolerated in animal studies.
- Multi-targeted kinase inhibitor.
- Inhibits HUVEC growth.
- Shows antiproliferative effects on leukemia cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Results in dose-dependent inhibition of tumor growth in vivo.
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