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AdipoGen Enoxacin
Supplier: AdipoGen AGCR13539M250
Chemical. CAS 74011-58-8. Formula C15H17FN4O3. MW 320.3. Enoxacin is a cell permeable fluoroquinolone broad-spectrum antibacteral agent. It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria. Fluoroquinolones are a group of broad-spectrum antibiotics that inhibit DNA synthesis. They prevent unwinding of double-stranded DNA by binding DNA gyrase or DNA topoisomerase IV, prevent the formation of single-stranded DNA and inhibit bacterial replication. Enoxacin is used to treat urinary tract infections and gonorrhea. Osteoclastogenesis inhibitor. Shown to decrease RANKL-induced JNK signaling and inhibiting osteoclast formation. Additionally, Enoxacin inhibits vacuolar H ATPase activity, preventing bone resorption. Enoxacin is a unique small molecule enhancer of microRNA SMER maturation. MicroRNAs miRNAs are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways.
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