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Apexbio Technology LLC Enoxolone 471-53-4 1g
Supplier: Apexbio Technology LLC B59861000
Enoxolone (CAS 471-53-4) also known as glycyrrhetinic acid is a principal component of licorice with reported antiviral and antifungal activities It modulates corticosteroid signaling by inhibiting 11 -hydroxysteroid dehydrogenase (11 -HSD) isoenzymes in hepatic and renal tissues In rats the IC50 values for 18 -enoxolone-mediated inhibition of 11 -HSD activity are 0 09 M in liver and 0 36 M in kidney homogenates Enoxolone also suppresses 11 -HSD activity in human JEG-3 choriocarcinoma cells This compound is used in biomedical research to study glucocorticoid metabolism mineralocorticoid receptor specificity and enzyme regulation in steroidogenesis
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