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Cayman Chemical ENPP1ENPP3 CelBased ActIvI 96

Supplier: Cayman Chemical 70208096 WELL

A PAC1 receptor antagonist selectively inhibits PACAP-induced CREB phosphorylation in CHO cells expressing the PAC1 receptor over CHO cells expressing VPAC1 or VPAC2 at 10 nM inhibits PACAP-induced cAMP accumulation in CHO cells expressing the PAC1 receptor (IC50 2 nM) intrathecal administration reduces PACAP-induced transient aversive behaviors and mechanical allodynia in mice at 100 pmol/animal
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