Medchemexpress LLC Ensartinib | 1365267-27-1 | 98.10% | 547.41 | 10 MM * 1 ML

Supplier:  Medchemexpress LLC HY1659010MM/1ML

X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM), exhibiting potent anti-tumor activity. This compound shows substantial bioavailability and moderate half-lives in vivo. Intended for research use only, animal studies indicate it is well-tolerated at effective doses without significant toxicity up to 50 mg/kg in SD rats.

• Potent ALK inhibitor (IC50: 0.61 nM)
• Inhibits MET (IC50: 0.69 nM)
• Potent in H3122, H2228, and SUDHL-1 cancer cells
• Soluble in DMSO (100 mg/mL)
• Well-tolerated in vivo with anti-tumor activity
• Stock solution storage: -80°C for 2 years, -20°C for 1 year

Catalog No. 50-003-91801