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Cayman Chemical EnsIfentrIn 10mg
Supplier: Cayman Chemical 3876110 MG
A PDE3 inhibitor (IC50 = 0.4 nM); selective for PDE3 over PDE4 (IC50 = 1,479 nM); reduces the phytohemagglutinin-induced proliferation of isolated human monocytes; inhibits LPS-induced increases of TNF-α protein levels in isolated human monocytes (IC50 = 520 nM); increases cAMP levels in isolated human neutrophils at 10 µM; inhibits electric field stimulation-induced contractile responses in isolated guinea pig trachea in a concentration-dependent manner; intranasal administration inhibits histamine-induced bronchoconstriction and tracheal edema in guinea pigs at 25% w/w
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