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Apexbio Technology LLC Entrectinib 1108743-60-7 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B58595.1

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Entrectinib (CAS 1108743-60-7) is an orally bioavailable small molecule inhibitor targeting receptor tyrosine kinases specifically anaplastic lymphoma kinase (ALK) Dysregulated ALK activity is implicated in the progression of several cancers influencing cell proliferation and survival Entrectinib has demonstrated selective inhibition of ALK-induced tumor growth in cell-based assays Additionally in xenograft models of ALK-positive non-small cell lung cancer (NSCLC) Entrectinib crosses the blood-brain barrier suppressing intracranial tumor growth and improving survival outcomes in a dose-dependent manner Currently Entrectinib is undergoing Phase I/II clinical evaluation for treating ALK-expressing solid cancers

Catalog No. 50-000-63563


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