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Cayman Chemical EP2 Receptor (rat) Reporter Assay Kit, 1 ea
SDP

Catalog No. 502896897
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The EP2 receptor is one of four GPCRs that mediate the actions of PGE2.; The diverse effects of PGE2 acting via EP2 receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases.; Cayman's EP2 Receptor (rat) Reporter Assay Kit consists of a 96-well plate coated with a transfection complex containing DNA constructs for rat EP2 receptor and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (EP2 Receptor Reverse Transfection Plate).; Binding of agonists to EP2 initiates a signal transduction cascade resulting in expression of SEAP which is secreted into the cell culture media.; The kit is simple to use and can be easily adapted to high throughput screening for therapeutic compounds regulating the activation of EP2.; PGE2 is included in the kit for use as a positive control.

Catalog No. 50-289-6897 Supplier Cayman Chemical Supplier No. 6003401 EA
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The EP2 receptor is one of four GPCRs that mediate the actions of PGE2.; The diverse effects of PGE2 acting via EP2 receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases.; Cayman's EP2 Receptor (rat) Reporter Assay Kit consists of a 96-well plate coated with a transfection complex containing DNA constructs for rat EP2 receptor and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (EP2 Receptor Reverse Transfection Plate).; Binding of agonists to EP2 initiates a signal transduction cascade resulting in expression of SEAP which is secreted into the cell culture media.; The kit is simple to use and can be easily adapted to high throughput screening for therapeutic compounds regulating the activation of EP2.; PGE2 is included in the kit for use as a positive control.

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