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Sigma Aldrich Fine Chemicals Biosciences Epidermal Growth factor Re
Supplier: Sigma Aldrich Fine Chemicals Biosciences E2645500UN
Epidermal growth factor receptor (EGfR) belongs to a family of cell surface receptors called receptor tyrosine kinases (RTKs) and is also the most studied member of this family. It is made up of an ectodomain (ECD) which contains four subdomains called DI-DIV a transmembrane region and a cytoplasmic tyrosine kinase domain (TKD). Binding of the ligand induces conformational changes in the ECD which leads to the dimerization of EGfR. This results in the activation of the TKD and the subsequent signal transduction. This receptor has a molecular weight of A¼178kDa.
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