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Cayman Chemical EpInastInhydrochlorIde 100mg
Supplier: Cayman Chemical 18136100 MG
A histamine H1 receptor antagonist (apparent Kis = 1.41 and 1.62 nM using guinea pig cerebellar and lung membranes, respectively) and mast cell stabilizer; inhibits IgE-induced histamine, TNF-α, and IL-10 secretion in human CBMCs at 0.1 μg/ml; inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID50s = 5 and 0.1 mg/kg, respectively); inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID50 = 9.7 mg/kg, p.o.); topical administration reduces lid edema, tearing, and redness, as well as the number of neutrophils and eosinophils in the lid fornix, in a mouse model of atopic conjunctivitis
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