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Apexbio Technology LLC Epothilone A 152044-53-6 25mg
Supplier: Apexbio Technology LLC A162325
Epothilone A (CAS 152044-53-6) is a natural macrolide compound originally isolated from the myxobacterium Sorangium cellulosum It exerts its biological activity by stabilizing microtubules thereby disrupting microtubule dynamics required for cell division In vitro Epothilone A exhibits potent cytotoxicity against human cancer cell lines with an IC50 of 4 4 nM in HCT-116 colorectal carcinoma cells In SKOV-3 ovarian cancer cells the reported IC50 is 20 4 1 4 nM and antiproliferative activity surpasses that of paclitaxel in prolonged exposure assays Epothilone A research applications include elucidating mechanisms of microtubule stabilization and investigating antitumor effects in preclinical cancer models
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