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Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 10mM (in 1mL DMSO), CAS: 152044-54-7.
Supplier: Apexbio Technology LLC A16305.1
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
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