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Cayman Chemical EprInomectIn B1a 1mg
Supplier: Cayman Chemical 281301 MG
A potent inhibitor of Cdc7 (IC50 3 4 nM) 60 10 and 300-fold selective for Cdc7 over CK2 PIM1 and a panel of over 100 protein kinases respectively inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s 118 and 140 nM respectively) inhibits Cdc7-specific phosphorylation of MCM2 and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells inhibits MCM2 phosphorylation (ED50 3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model at 10 30 and 100 mg/kg
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