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Apexbio Technology LLC EPZ004777 HCl 1380316-03-9 50mg
Supplier: Apexbio Technology LLC B158150
EPZ004777 HCl (CAS 1380316-03-9) is a selective inhibitor of DOT1L a histone methyltransferase responsible for catalyzing methylation at lysine 79 of histone H3 (H3K79) It inhibits DOT1L enzymatic activity with an IC50 of approximately 400 pM In vitro studies demonstrate concentration-dependent suppression of H3K79 methylation and proliferation inhibition in various leukemia cell lines notably those harboring mixed lineage leukemia (MLL) rearrangements such as MV4-11 (MLL-AF4) and MOLM-13 (MLL-AF9) EPZ004777 serves as a valuable research tool for investigating epigenetic regulation in leukemia and exploring potential therapeutic targets
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