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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG
Supplier: Medchemexpress LLC HY15227A10MG
EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.
- Potent DOT1L inhibition (IC50 0.4 nM).
- Selective activity in biochemical and cellular assays.
- Reduces H3K79 methylation and downregulates leukemogenic gene expression.
- High chemical purity (99.5%).
- Available as solid and as DMSO solution for flexible use in experiments.
- CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.
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