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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 1 ML
Supplier: Medchemexpress LLC HY15227A10MM/1ML
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor (IC50 of 0.4 nM). It reduces H3K79me2 and H3K79me1 levels, significantly down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Significantly down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits proliferation of MLL rearrangement cells
- Promotes differentiation and apoptosis of leukemia cells
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