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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
Supplier: Medchemexpress LLC 25MGHY15227A
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
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