Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000372078

Medchemexpress LLC Epz004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 5 MG
SDP

Catalog No. 5000372078
Encompass_Preferred

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.

  • Selectively inhibits the proliferation of MLL rearrangement cells
  • Promotes the differentiation and subsequent apoptosis of leukemia cells
  • Can be utilized for leukemia research
  • Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
  • Remarkable selectivity for DOT1L over other HMTs

Catalog No. 50-003-72078 Supplier Medchemexpress LLC Supplier No. HY15227A5MG
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.

  • Selectively inhibits the proliferation of MLL rearrangement cells
  • Promotes the differentiation and subsequent apoptosis of leukemia cells
  • Can be utilized for leukemia research
  • Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
  • Remarkable selectivity for DOT1L over other HMTs

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.