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Medchemexpress LLC Epz004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 5 MG
Supplier: Medchemexpress LLC HY15227A5MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.
- Selectively inhibits the proliferation of MLL rearrangement cells
- Promotes the differentiation and subsequent apoptosis of leukemia cells
- Can be utilized for leukemia research
- Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
- Remarkable selectivity for DOT1L over other HMTs
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