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Medchemexpress LLC Epz020411 (hydrochloride) | 2070015-25-5 | 98.15% | 10MM 1ML
Supplier: Medchemexpress LLC HY12970A10MM/1ML
EPZ020411 hydrochloride is a selective inhibitor of PRMT6 with an IC50 of 10 nM. It demonstrates more than 10-fold selectivity for PRMT6 over PRMT1 and PRMT8 and can be used for cancer research.
- Selective inhibitor of PRMT6 (IC50 of 0.01 μM).
- Exhibits over 10-fold selectivity for PRMT6 compared to PRMT1 and PRMT8.
- Decreases H3R2 methylation in A375 cells.
- Reduces neomycin- and cisplatin-induced cell apoptosis and increases hair cell survival.
- Attenuates neomycin- and cisplatin-induced hearing loss in mice.
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