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Medchemexpress LLC EPZ020411 hydrochloride | 2070015-25-5 | 98.2% | 50 MG
Supplier: Medchemexpress LLC HY12970A50MG
EPZ020411 hydrochloride is a potent and selective inhibitor of protein arginine methyltransferase 6 (PRMT6) with an IC50 of 10 nM. It exhibits over 10-fold selectivity for PRMT6 compared to PRMT1 and PRMT8. This compound is valuable for cancer research and has demonstrated the ability to decrease H3R2 methylation in A375 cells, as well as reduce neomycin- and cisplatin-induced cell apoptosis, thereby increasing hair cell survival.
- Selective inhibitor of PRMT6
- IC50 of 10 nM for PRMT6
- Over 10-fold selectivity for PRMT6 over PRMT1 and PRMT8
- Can be used for cancer research
- Decreases H3R2 methylation in A375 cells
- Reduces neomycin- and cisplatin-induced cell apoptosis
- Increases hair cell survival
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