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Medchemexpress LLC Erenapurstat | 136164-66-4 | 99.67% | 378.46 | 50 MG
Supplier: Medchemexpress LLC HY1935750MG
Erenapurstat (E3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. It impairs tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer, showing anticancer activities.
- Targets Ape-1 and Ref-1
- Inhibits growth of HUVECs, PCECs, and EPCs
- Reduces VEGF expression in pancreatic cancer cells
- Inhibits differentiation of BM-MSCs into CD31+ endothelial lineage cells
- Decreases cell viability in H1975 cells
- Inhibits growth and migration of pancreatic cancer cells
- Enhances intracellular ROS level and inhibits CD44 expression in PANC1 cells
- Neuroprotective against cisplatin-induced alterations
- Attenuates liver injury in rats
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