Apexbio Technology LLC Erlotinib 183321-74-6 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A33975.1

Erlotinib (CAS 183321-74-6) is an orally bioavailable reversible inhibitor targeting the epidermal growth factor receptor (EGFR) tyrosine kinase It acts by competitively binding the intracellular ATP-binding domain of EGFR thereby preventing receptor autophosphorylation and subsequent signaling cascades involved in proliferation angiogenesis and cell survival In biochemical assays Erlotinib demonstrates potent inhibition of EGFR tyrosine kinase (IC50 2 nmol/L) and cellular autophosphorylation of EGFR (IC50 20 nmol/L) Due to its selective interference with EGFR-mediated signaling Erlotinib is extensively employed in oncology research particularly in studies on EGFR-expressing tumor models

Catalog No. 50-000-64156