Invitrogen™ Human ERN2, GST Tag Recombinant Protein

Description

Recombinant Protein

ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Specifications

• Accession Number: Q76MJ5
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5
• Gene ID (Entrez): 10595
• Molecular Weight (g/mol): 79.6 kDa
• Name: Human ERN2, GST Tag
• Quantity: 10 μg
• Gene Alias: endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 2; Ern1; ern2; hIRE2p; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; inositol-requiring protein 2; Ire1; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1b; ire1-beta; IRE2; IRE2p; mIre1; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE2
• Common Name: ERN2
• KinaseFamily: IRE Family
• Protein Length: 499-end
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Active, Catalytic
• Form: Liquid