Invitrogen™ Human ERN2, GST Tag Recombinant Protein

Catalog No.	Quantity
A33375	1 mg
A30972	10 μg
A32890	100 μg

Catalog No. A33375 Supplier Invitrogen™ Supplier No. A33375

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This ERN2 recombinant human protein (499-end) was expressed in insect cells. ERN2 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen™ Eu Kinase Binding assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic. The gene accession number for ERN2 is NP_150296.4.

ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Specifications

• Accession Number: Q76MJ5
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 25% glycerol, 0.25mM DTT, 0.1mM EDTA, 150mM NaCl, 0.1mM PMSF, 10mM glutathione and no preservative; pH 7.5
• Gene ID (Entrez): 10595
• Molecular Weight (g/mol): 79.6 kDa
• Name: Human ERN2, GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum to nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 2; Endoribonuclease; ER to nucleus signalling 2; Ern1; ern2; hIRE2p; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; inositol-requiring protein 2; Ire1; IRE1 beta; IRE1, S. cerevisiae, homolog of; Ire1b; ire1-beta; IRE2; IRE2p; mIre1; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE2
• Common Name: ERN2
• Gene Symbol: ERN2
• Kinase Family: IRE Family
• Protein Length: 499-end
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 499-end
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Shipping Condition: Dry Ice
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Active, Catalytic
• Form: Liquid