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Cayman Chemical Esaxerenon 100mg
Supplier: Cayman Chemical 41082100 MG
A non-steroidal mineralocorticoid receptor antagonist (IC50 = 9.4 nM); selective for mineralocorticoid receptors over glucocorticoid, androgen, and progesterone receptors (IC50s = >10,000 nM for all); increases the urinary ratio of sodium to potassium in bilateral adrenalectomized rats at 0.3, 1, or 3 mg/kg; decreases systolic blood pressure in DOCA-salt hypertensive rats at 3 mg/kg; reduces systolic blood pressure, urinary protein levels, blood levels of BNP, kidney and left ventricle weights, and glomerulosclerosis, as well as increases blood potassium levels, in Dahl salt-sensitive rats fed a high-salt diet at 2 mg/kg per day
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