β-Estradiol, MP Biomedicals™

Description

β-Estradiol is a potent mammalian estrogenic hormone produced by the ovary. Triggers the production of gonadotropins, leading to ovulation.

Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation.

• The major estrogen secreted by the premenopausal ovary.
• Exposure to estradiol increases breast cancer incidence and proliferation.

Specifications

Chemical Identifiers

• CAS: 50-28-2
• Molecular Formula: C18H24O2
• Molecular Weight (g/mol): 272.388
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Synonym: estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
• PubChem CID: 5757
• ChEBI: CHEBI:16469
• IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

• Melting Point: 173°C to 179°C
• Quantity: 250 mg
• Solubility Information: Almost insoluble in water (50mg/mL; clear, colorless solution). Freely soluble in alcohol; soluble in acetone, dioxane, other organic solvents; solutions of fixed alkali hydroxides; sparingly soluble in vegetable oils; soluble in methanol:CHCl3 (1:1).
• Optical Rotation: +76.8 (Concentration = 1, Solvent = Dioxane) (Lit.)
• Formula Weight: 272.39g/mol
• Grade: Cell Culture Reagent
• Physical Form: Powder

Safety and Handling

Recommended Storage

Store at Room Temperature (15–30°C). Store under nitrogen.

WARNING: Cancer - www.P65Warnings.ca.gov