Cayman Chemical Estrogen Receptr BIoasy 96Wel

Supplier:  Cayman Chemical 4103496 WELL

A BD2 bromodomain inhibitor inhibits BD2 in BRD2 BRD3 and BRD4 (IC50s 0.08 0.05 and 0.02 UM respectively) and is selective for BD2 over BD1 (IC50s 3.76 2.34 and 1.16 UM for BRD2 BRD3 and BRD4 respectively) as well as CREBBP and p300 (IC50s 50 UM for both) decreases levels of the mRNAs encoding IL-6 and VCAM-1 in primary synovial fibroblasts isolated from patients with rheumatoid arthritis at 10 and 30 UM It prevents LPS-induced increases in IL-6 and Ifn-Y serum levels in a mouse model of LPS-induced endotoxemia at 75 mg/kg inhibits collagen-induced increases in ankle and knee diameter cartilage damage the ankle tissue levels of mRNAs encoding IL-1B Mmp-3 Mmp-13 and Rankl and ankle joint protein levels of IL-6 and VCAM-1 in a rat model of collagen-induced rheumatoid arthritis at 25 50 and 75 mg/kg twice per day improves gait and mobility and reverses body w8 loss as well as decreases the number of spinal cord inflammatory foci and apoptotic cells

Catalog No. 50-294-2775