Medchemexpress LLC ETC-159 | 1638250-96-0 | 99.1% | 391.38 | 100 MG

Supplier:  Medchemexpress LLC HY18988100MG

ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM. ETC-159 blocks the secretion and activity of all Wnts and shows robust activity in multiple cancer models driven by high Wnt signaling. It is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations.

• Potent, orally available PORCN inhibitor.
• Inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
• Blocks the secretion and activity of all Wnts.
• Exhibits robust activity in various cancer models driven by high Wnt signaling.
• Highly efficacious in colorectal cancers (CRCs) with R-spondin translocations.
• Inhibits mouse PORCN with an IC50 of 18.1 nM.
• Demonstrates good oral pharmacokinetics in mice with 100% oral bioavailability after a single oral dose of 5 mg/kg.

Catalog No. 50-003-85762