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Apexbio Technology LLC Ethacrynic Acid 58-54-8 200mg
Supplier: Apexbio Technology LLC C4125200
Ethacrynic acid (CAS 58-54-8) is a small molecule loop diuretic that exerts its effects by inhibiting the Na sup /sup -K sup /sup -2Cl sup /sup cotransporter (NKCC2) localized in the thick ascending limb of the loop of Henle This inhibition interrupts reabsorption of sodium potassium and chloride ions leading to increased concentrations of these electrolytes in the renal tubular fluid and decreased medullary osmolarity As a result water reabsorption is reduced promoting diuresis and subsequent urinary excretion Ethacrynic acid is frequently utilized in research investigating renal function electrolyte transport mechanisms and pathophysiology of edematous states including heart failure nephrotic syndrome and hepatic conditions
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