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Ethacrynic acid

Catalog No. AAJ6368403
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Catalog No. AAJ6368403 Supplier Thermo Scientific Chemicals Supplier No. J6368403
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Description

CAS: 58-54-8 | C13H12Cl2O4 | 303.135 g/mol

Ethacrynic acid is used to inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Ethacrynic acid is used to inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, in
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 58-54-8
Molecular Formula C13H12Cl2O4
Molecular Weight (g/mol) 303.135
MDL Number MFCD00056693
InChI Key AVOLMBLBETYQHX-UHFFFAOYSA-N
Synonym ethacrynic acid, etacrynic acid, ethacrynate, etacrinic acid, hydromedin, edecrin, crinuryl, edecril, edecrina, endecril
PubChem CID 3278
ChEBI CHEBI:4876
IUPAC Name 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
SMILES CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl

Specifications

Color White
Quantity 1 g
Merck Index 14,3717
Solubility Information Soluble in ethanol,chloroform,ether,ammonia,carbonates,and methanol. Insoluble in water.
Formula Weight 303.14
Physical Form Crystalline Powder
Chemical Name or Material Ethacrynic acid

Safety and Handling

Hazard Category H302+H312+H332-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber 200-384-1
RTECSNumber AG6600000
TSCA No
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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