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Medchemexpress LLC Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate) | 1119249-30-7 | 98.2% | 250 MG
SDP

Supplier:  Medchemexpress LLC 250MGHY130162

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Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker used in the synthesis of Thalidomide-O-PEG2-propargyl. It functions as a click chemistry reagent, incorporating an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

  • PEG-based PROTAC linker
  • Click chemistry reagent
  • Contains an alkyne group
  • Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
  • Can be used to synthesize Thalidomide-O-PEG2-propargyl
  • Exploits the ubiquitin-proteasome system
  • Selectively degrades target proteins

Catalog No. 50-003-41489


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